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Defined Test Material Exposure Assessment Acute Toxicity Genetic Toxicology Metabolism Pharmacokinetics Reject Accept Subchronic Toxicity Reproduction Reject Reject Chronic Toxicity Accept Reject Accept presentssociallyunacceptable risk - doesnotpresentasociallyunacceptable risk S metabolites knownand safe U metabolites unknown or of doubtful safety .Nieves-Neira, W.
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