2 Origin of changes in allele frequencies and allele transmissions for genes acting in mothers only, cases only or through maternal imprinting Elevated allele frequency in cases Elevated allele frequency in mothers Elevated allele frequency in fathers Overtransmission of maternal allele Overtransmission paternal allele Gene acting in mothers only By enrichment Causative No No No Gene acting in cases only Causative By enrichment By enrichment Yes Yes Maternal imprinting Causative By enrichment No Yes No The table characterizes the effects of genes acting solely in mothers, solely in offspring, or via maternal imprinting in terms of the susceptibility allele frequencies in cases and parents.
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